Lettuce is one of the most efficient and rewarding things to grow in hydroponics. Under good conditions, they usually sprout within about three days; it's actually not unheard of for them to literally sprout overnight. (Don't be alarmed, though, if it takes a week or two. There are so many things that can affect how quickly a seed germinates!) They are ready to begin harvesting just as rapidly, usually starting about a mere 21-24 days after the seeds are started. It feels like you can literally watch the little plants growing in real time!
But once your baby lettuce is reaching a harvestable size, then what?
When it comes to lettuce, there are two primary methods of harvesting: the "haircut" method, where you cut across all, or at least the majority, of leaves at a certain point; and the "leaf at a time" method, where you pick the outside leaves around the plant in a spiral. Which of the two you use is entirely a personal choice; some swear by one, some the other. Like most things, both have pros and cons, and so which you choose to employ comes down to your specific garden and goals. In my personal experience, and reading the experiences of others, this is what I have picked up: